CJC-1295 DAC ( 2 Mg)

CJC-1295 is a modified fragment of native GHRH, optimized for:

• High receptor affinity

• Resistance to enzymatic degradation

The defining feature is the Drug Affinity Complex (DAC).

What DAC Does DAC enables the peptide to:

• Bind reversibly to serum albumin

• Remain in circulation for extended periods

• Maintain prolonged biological activity

This modification extends the half-life from minutes (native GHRH) to several days, making CJC-1295 + DAC a long-acting GH secretagogue.

A. GHRH Receptor Activation CJC-1295 + DAC binds to GHRH receptors on somatotroph cells in the anterior pituitary gland. This binding:

• Triggers intracellular cAMP signaling

• Increases transcription and release of GH

• Enhances amplitude and frequency of GH pulses

Crucially, GH release remains pulsatile, not continuous-mirroring natural physiology.

B. Downstream GH-IGF-1 Axis The elevated GH pulses then:

• Act directly on peripheral tissues (lipolysis, protein sparing)

• Stimulate hepatic production of IGF-1

The result is a system-wide anabolic and regenerative signaling environment, achieved indirectly and under endogenous control.

• Protein Preservation and Anabolism

GH reduces proteolysis and supports long-term tissue maintenance without forcing direct muscle hypertrophy.

• Lipolysis and Fat Mobilization

• GH promotes fatty acid release from adipose tissue, shifting energy utilization toward fat.

• Recovery and Tissue Repair

Enhanced GH signaling supports:

• Connective tissue integrity

• Collagen synthesis

• Cellular recovery processes

• Sleep-Linked Optimization

Because GH pulses are strongest during deep sleep, CJC-1295 + DAC aligns naturally with circadian endocrine rhythms.