Semax is a synthetic neuroactive peptide derived from a modified fragment of adrenocorticotropic
hormone (ACTH 4-10).
Crucially, it was engineered to retain cognitive and neuroprotective properties while eliminating
hormonal (adrenal-stimulating) activity.
As a result, Semax functions as a pure neuromodulator, not a hormone.
Semax (10 Mg)
Semax consists of a short peptide sequence optimized for:
- High stability against enzymatic degradation
- Ability to influence central nervous system signaling
- Absence of corticosteroid stimulation
This design allows Semax to act directly on brain signaling pathways without affecting cortisol or adrenal hormone output.
A. BDNF and Neuroplasticity
One of Semax's most significant actions is the upregulation of neurotrophic factors, especially:
- Brain-Derived Neurotrophic Factor (BDNF)
- Nerve Growth Factor (NGF), to a lesser extent
Through activation of TrkB-related pathways, Semax:
- Enhances synaptic plasticity
- Supports learning and memory consolidation
- Strengthens neuronal resilience
This positions Semax as a plasticity-enhancing peptide, rather than a stimulant.
B. Neurotransmitter Modulation
Semax modulates multiple neurotransmitter systems in a balanced, regulatory manner:
- Dopaminergic signaling (motivation, focus)
- Cholinergic efficiency (memory encoding)
- Stabilization of glutamatergic signaling (learning without excitotoxicity)
Importantly, it does not force neurotransmitter release; it optimizes signal efficiency.
